Signaling pathways associated to steroidogenesis

Abstract

The biosynthesis of steroid hormones is necessary to maintain reproductive functions and body homeostasis. This process, which is carried out in acutely and chronically regulated steroidogenic tissues, depends on the activation of signaling pathways particularly mediated by the cyclic adenosine monophosphate dependent protein kinase (PKA). Data obtained by our and other groups in human placenta and other tissues, have clearly showed that dynamic phosphorylation catalyzed by PKA is related to steroidogenesis, including its hormonal regulation. It is known, however, that this process also involves the participation of other PKA independent signaling cascades, which are activated by trophic hormones, cytokines or growth factors and others such as calcium, chloride ions and arachidonic acid metabolites. The understanding of the stimulating factors, as well as the mechanisms that regulate the synthesis of steroid hormones, will allow us the identification of potential intervention sites that may contribute to maintain body homeostasis and different functions depending on them.