The Randle cycle, the precarious link between sugars and fats

Abstract

Obesity is a growing global health concern, closely related to cardiovascular diseases. Understanding the correlation between excessive sugar consumption and the formation of fat deposits, described in the Randle cycle, will allow us to have a better grasp on metabolic processes that disrupt the balance between fat formation and degradation processes. The goal of this review is to expand and update the information about the Randle cycle and describe their different levels of regulation. In addition, the participation of mTORC1 and the AMP dependent Kinase (AMPK) during the postprandial and fasting states is described.